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KMID : 0613820130230040510
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Journal of Life Science
2013 Volume.23 No. 4 p.510 ~ p.517
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Inhibition of Adipocyte Differentiation and Adipogenesis by Supercritical Fluid Extracts and Marc from Cinnamomum verum
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Park Sung-Jin
Lee In-Seon
Lee Sam-Pin
Yu Mi-Hee
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Abstract
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This study was performed to evaluate the antiobesity effect of supercritical fluid extracts (SFC) and marc methanol extracts (SFM) from Cinnamomum verum in 3T3-L1 preadipocytes. In inducing the differentiation of 3T3-L1 preadipocytes in the presence of an adipogenic cocktail, iso-butylmethylanthine (IBMX), dexamathasone, and insulin, treatment with fraction residue SFC and SFM. SFC significantly reduced the mRNA expression of the transcription factor peroxisome proliferator-activate-dreceptor-r(PPARr), the sterol regulatory-element-binding protein-1c (SREBP1c), and the CCAAT enhancer-binding-protein α(C/EBPα) in a concentration-dependent manner. Moreover, SFC markedly down-regulated acyl-CoA synthetase-1 (ASC1), fatty acid synthesis (FAS), fatty acid transport-1 (FATP1), fatty acid binding protein 4 (FABP4), and perilipin. These findings suggest that SFC may be a potential therapeutic adjunct for obesity by targeting the differentiation of preadipocytes, as well as their functions.
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KEYWORD
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Adipocyte, anti-obesity, CCAAT enhancer-binding-protein α(C/EBPα), Cinnamomum verum, peroxisome-proliferators-activated-receptor-r(PPARr)
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